In vivo SilenceMag™ is a rapid, simple and highly efficient method dedicated to transfect small RNA (siRNA, miRNA) into target cells/tissue in vivo. It combines magnetic nanoparticles and small RNA that will be retained after injection at the magnetically targeted site. This targeted delivery method minimizes systemic distribution, increases gene targeted inactivation and reduces toxicity. Furthermore, the magnetic forces enhance the uptake of magnetic nanoparticles by the target tissue, and thus improve the efficiency of silencing.
This allows decreasing the required process time of delivery to few minutes which is crucial for improvement of in vivo small RNA delivery. In vivo SilenceMag™ is designed to meet in vivo grade quality.
In vivo SilenceMag™ benefits:
- Increased silencing efficiency
- Targeted process (magnetically-driven)
- Reduction of the systemic dissemination of siRNA/miRNA during injection
- Reduction of the siRNA/miRNA doses
- Work under non permissive conditions (hypothermia, physiological flow conditions)
- Penetration of the siRNA/miRNA into tissues
- Minimized toxicity
Storage: +4°C
Shipping Conditions: Room temperature
- NB: This reagent needs to be used with a magnet
